Frequency of ICU mortality and thrombocytopenia in patients with sepsis

Abstract Introduction: Thrombocytopenia in patients with sepsis was found to be associated with a poorer outcome. Rationale of this study was to gather data in our settings to assess the association between thrombocytopenia and intensive care unit (ICU) mortality in such patients. This will help us in devising proactive management guidelines for improving the outcomes in these patients. Objectives: To determine the frequency of thrombocytopenia in patients with sepsis and to compare the frequency of ICU mortality in patients with sepsis with and without thrombocytopenia Materials and Methods: A total of 200 patients irrespective of gender between ages of 18-75 years who admitted to the ICU with sepsis was included to the study. Frequency of thrombocytopenia was measured and ICU mortality was compared between patients with and without thrombocytopenia. Results: 64.5% (n = 120) of patients were males and 35.5% (n = 71) of patients were females. 59.9% (n = 118) of patients had thrombocytopenia and overall mortality study subjects was 64.5% (n = 129). In patients with thrombocytopenia, mortality was significantly higher (72.9% versus 52.4%) as compare to patients without thrombocytopenia (P < 0.05).Gender and age based stratification showed mortality was higher in males and older age group with thrombocytopenia (P < 0.05). Conclusion: Significant percentage (59.9%) of patients admitted with sepsis in ICU were found to have thrombocytopenia. Mortality was significantly higher in these patients as compared to those patients recruited in group who did not have thrombocytopenia. Core tip In a study on 200 patients between ages of 18-75 years who admitted to the ICU with sepsis, we found a significant percentage (59.9%) of patients admitted with sepsis in ICU were found to have thrombocytopenia. Mortality was significantly higher in these patients as compared to those patients recruited in group who did not have thrombocytopenia. Thrombocytopenia in patients with sepsis was found to be associated with a poorer outcome. Rationale of this study was to gather data in our settings to assess the association between thrombocytopenia and ICU mortality in such patients. This will help us in devising proactive management guidelines for improving the outcomes in these patients. Citation Batool A, Tanveer A, Memon MI, Nazar CMJ, Tahir H. Frequency of ICU mortality and thrombocytopenia in patients with sepsis.  J Prev Epidemiol. 2016;1(2):e14.