The relationship between protein synthesis and protein degradation in object recognition memory

For decades there has been a consensus that de novo protein synthesis is necessary for long-term memory. A second round of protein synthesis has been described for both extinction and reconsolidation. Recently, it was demonstrated that consolidation and reconsolidation depend not only on protein syn­thesis but also on protein degradation by the ubiquitin-proteasome system (UPS). However, the involvement of UPS on consolidation and reconsolidation of object recognition memory (OR) remains unclear.