Intraluminal Prucalopride Increases Propulsive Motor Activities in the Human Colon

High-resolution colonic manometry and biopsy immunohistochemistry revealed that 5-HT4 receptors in the lumen of the human colon are present exclusively on enterochromaffin cells and the 5-HT4 receptor agonist prucalopride, evokes all major propulsive motor patterns, associated with significant anal sphincter relaxation, when given intraluminally.