Myasthenia gravis in Jamaican children: a 12-year institutional review

AbstractBackground: Myasthenia gravis is uncommon in children. The clinical characteristics in children of the English-speaking Caribbean have not been documented previously.Objective: To describe the clinical characteristics and outcome of children with myasthenia gravis at two tertiary hospitals in Jamaica.Methods: The case-notes of all children with a diagnosis of myasthenia gravis managed at the University Hospital of the West Indies and Bustamante Hospital for Children between January 1994 and December 2005 were reviewed.Results: There were 34 children; mean age of onset of illness was 7·5 years and mean period of follow-up was 38·5 months. The male-to-female ratio was 1∶1·3. Nineteen (59%) presented with ocular manifestations; 47% of these developed signs of generalised involvement. Most were treated with pyridostigmine and prednisone. Eight patients had thymectomy. Four patients (12%) entered remission. There were two deaths.Conclusions: Myasthenia gravis in Jamaican children is similar to that in ...