Clinical study of alprostadil combined with epalrestat and methylcobalamin in the treatment of type 2 diabetic peripheral neuropathy

Objective To study the effect of alprostadil combined with epalrestat and methylcobalamin in the treatment of type 2 diabetic peripheral neuropathy. Methods From January 2014 to June 2016, 120 patients with type 2 diabetic peripheral neuropathy in the First People′s Hospital of Baiyin were randomly divided into two groups according to the random number table method.64 patients of the observation group were given the treatment of alprostadil, epalrestat combined with methylcobalamin.56 patients of the control group were given the treatment of alprostadil and methylcobalamin.And the two groups were treated for 4 weeks.The blood glucose, clinical symptoms, adverse reaction, nerve conduction velocity index were compared between the two groups before and after treatment. Results The fasting blood glucose and 2-hour postprandial blood glucose of the two groups after treatment were significantly decreased(t=18.20, 17.61, 15.75, 23.69, all P 0.05). Conclusion Alprostadil combined with epalrestat and methylcobalamin in the treatment of type 2 diabetic peripheral neuropathy has good effect. Key words: Diabetic neuropathies; Alprostadil; Epalrestat; Methylcobalamin