Efficiency of fenticonazole for the treatment of vaginal candidiasis
2012
Introduction. Uncomplicated vulvovaginal candidiasis appears in 75% women of
reproductive age. The most frequent causes are Candida albicans (85-95%) or
C. glabrata, and infrequently C. krusei, C. tropicalis, C. parapsilosis, C.
pseudotropicalis, etc. Objective. The aim of the study was to investigate
efficiency and safety of fenticonazole for vaginal candidiasis treatment.
Methods. Therapeutic effect of a single 600 mg fenticonasole vaginal capsule
was observed in 417 women, aged 16-67, in five centers in Serbia. In all
women, before the treatment, vaginal candidiasis was confirmed by testing of
vaginal smear. Based on smear findings and associated symptoms observed on
the 7th and 28th day after therapy administration, treatment results were
evaluated. On the next day after drug application the patients recorded by
using a questionnaire their own feelings on withdrawal symptoms and possible
side effects in the period prior to the first control. Results. Control after
seven days showed a statistically significant decrease of symptoms. In 385
women, vaginal smear was found negative to yeast and yeast blastospores.
Within the first seven days after treatment 84 women had to repeat therapy
due to the persistence of symptoms or positive vaginal smear. After 28 days
we recorded full recovery in 392 patients, clinical improvement in eight, no
change in 16, and deterioration in one patient only. Side effects were very
seldom, mostly in the form of a slight redness of the vulva and vagina, and
mild itching during several days. Conclusion. Our observations confirmed good
efficacy and safety of fenticonazole in the treatment of vaginal candidiasis.
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