Bcl-2、Bcl-xL和Bax蛋白在结直肠癌中的表达

BACKGROUND & AIM: To investigate the role of Bcl-2, Bcl-xL and Bax protein in colorectal carcinomatous tumorigenesis by detecting their expression in cancerous and adjacent tissues (＞5cm from the cancerous tissue). MATERIALS AND METHODS: The expression of Bcl-2, Bcl-xL and Bax protein by S-P staining were detected in 39 colorectal cancerous tissues and adjacent tissues. RESULTS: The expression of Bcl-2 protein were often absent or weak, and no significant difference between cancerous tissue and adjacent tissue was found (Z=0.072, P＞0.05). On the contrary, the immunostaining intensity of Bcl-xL protein was higher and stronger in cancerous tissues than adjacent tissues (Z=3.157, P＜0.05), The immunostaining intensity of Bax protein was the strongest, but showed no significant difference between 4ancerous and adjacent tissues (Z=1.707, P＞0.05). Only the expression of Bcl-2 protein demonstrated a negative correlation with Dukes and TNM stages(r(subscript s)=-0.389,-0.396, P＜0.05), all others had no relationship with clinicopathological parameters (P＞0.05). CONCLUSION: Bcl-2 gene might play an important role in the early stage of colorectal carcinomas, however, Bcl-xL gene might be more important in the later stage. On the other hand, Bcl-2 protein expression may correlate with prognosis.