Phase sensitive optical coherence microscopy for photothermal imaging of gold nanorods
2018
We describe a swept source based phase sensitive optical coherence microscopy (OCM) system for photothermal
imaging of gold nanorods (GNR). The phase sensitive OCM system employed in the study has a displacement sensitivity
of 0.17 nm to vibrations at single frequencies below 250 Hz. We demonstrate the generation of phase maps and confocal
phase images. By displaying the difference between successive confocal phase images, we perform the confocal
photothermal imaging of accumulated GNRs behind a glass coverslip and behind the scattering media separately.
Compared with two-photon luminescence (TPL) detection techniques reported in literature, the technique in this study
has the advantage of a simplified experimental setup and provides a more efficient method for imaging the aggregation
of GNR. However, the repeatability performance of this technique suffers due to jitter noise from the swept laser source.
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