Синтез, противоопухолевые и антимоноаминоксидазные свойства 2,4,4-тризамещенных триазолобензо[h]хиназолинов

The N-(2-cyano-3-ethyl-3-methyl-3,4-dihydronaphthalene-1-yl)propanamide (II) is synthesized by condensation of 1-amino-3-ethyl-3-methyl-3,4-dihydronaphthalene-2-carbonitrile (aminonitrile I) with propionic chloride. The cyclisation of synthesized compound has resulted 2,5-diethyl-5-methyl-5,6-dihydrobenzo[h]quinazoline-4(3H)-one (III). The reaction of aminonitrile I with orthoformic ether and the subsequent interaction of intermediate formed product with hydrazides aromatic and alkylaromatic carbonic acids triazoles IV - XVIII are received, condensed with benzo[h]quinazolines in position c of the last. Antimonoaminoxidaze and antineoplastic properties of the synthesized compounds are studied. Some of the synthesized compounds have shown 40 - 50 % antimonoaminoxidaze activity.