The Effect of Inert Gases on Ion Transport Across the Erythrocyte Membrane.

Abstract : Hyperbaric argon stimulates active transport of sodium and potassium in the human erythrocyte. These increases in active uptake of potassium and active extrusion of sodium from the cell are related to the partial pressure of the ENG. Moderate hydrostatic pressures (as exerted through helium, an ENNG) depress active transport in these same cells. This depression is seen under hyperbaric pressures of argon-helium mixtures to exert an effect proportional to the pressure exerted. Nitrogen, a less potent ENG than argon, increases active transport across cell membranes but to a lesser degree. This shows again the parallel between the behavioral actions of hyperbaric ENGs and their effects on cell membrane ion transport. Although active transport is stimulated by ENGs and inhibited by pressure, the ability of Na-K, ATPase (the transport enzyme) of cell membranes to hydrolize ATP is not affected by these conditions. This suggests that the effects of pressure and ENGs may be on the stochiomestry or efficiency of the pump rather than on its activity per se.