Effects of Anion in the Rat with Adjuvant-induced Arthritis

This study was performed to elucidate the effects of anion in the rats with adjuvant-induced arthritis. Rats were divided four groups: control (group I, n=10), arthritis (group II, n=10), arthritis with non-operation of anion generator (group III, n=10) and arthritis with operation of anion generator (group IV, n=10). Serum IL-6 and TNF-α levels were measured and histological findings of knee joints were observed in all groups. The IL-6 and TNF-α levels in group III and IV were significantly lower than those of group II. The IL-6 and TNF-α levels in group IV were significantly lower than those of group III. The inflammatory and damage degrees on the knee joints were lower in group III and IV than in group II. The degree of joint injury in group IV was less than that of group III. We first revealed that anions made by anion-generator may attenuate inflammatory and damaging effects of the arthritis. However, further study should be performed in human.