The effect of repeated instillation of insulin into the conjunctival sac on the course of alloxan diabetes

In experiments on 51 rabbits the instillation of insulin (240 units/ml) into the conjunctival sac of animals with alloxan diabetes leads to a considerable drop of the sugar level of the blood and urine, and a reduction of diuresis. In individual cases there is a normalization of the blood sugar indices with an absence of sugar in the urine for several days after the interruption of instillation. A marked action of insulin is observed from 30 minutes to 1 hour after the administration. Clinical and pathologico-histological investigations of the conjunctiva, cornea and deep media of the eyes showed no changes connected with this method of insulin administration.