CHARACTERIZATION OF STATIONARY MOBILE PHASE COMBINATIONS BY USING MARKERS .1. PRELIMINARY-RESULTS FOR THE PREDICTION OF REVERSED-PHASE RETENTION ON VARIOUS STATIONARY PHASES

Abstract The characterization of stationary/mobile phase combinations can be done in a phenomenological way by measuring the k ′ values of specific solutes, the markers. These markers can be chosen optimally from a set of test solutes with the use of multivariate techniques. When retention data of solutes on different stationary phases, with varying mobile-phase compositions, are available, a procedure is given to predict the retention of those solutes on new stationary phases. This procedure uses markers to characterize the new stationary/mobile phase combinations.