Inhibition of exocrine pancreatic secretion by glucagon and D-glucose given intravenously

The actions of glucagon and D-glucose on blood glucose and exocrine pancreatic secretion in response to secretin were studied in unanesthetized dogs with chronic pancreatic fistulas, gastric fistulas, and a gastroenterostomy which diverted gastric acid from the duodenum. Both glucagon and D-glucose, when given intravenously, produced significant and dose-related inhibition of the volume of pancreatic secretion and of the protein, amylase, lipase, and protease outputs. There was a linear inverse relationship between pancreatic enzyme output and blood glucose levels following glucagon or D-glucose infusion. Statistical analysis of the data showed that the slopes of the lines relating blood glucose to amylase, to lipase, and to protease were significantly different from each other, indicating preferential inhibition for amylase.