Clinical evaluation of two serological methods for detecting Treponema pallidum

Objective To explore the diagnostic value of TRUST and TPPA in diagnosis of human syphilis and provide experimental theory for the clinical purpose.Methods TRUST and TPPA were used to detect 2 083 serum specimens(including 910 syphilis serum specimens).Results There were 773 positives were detected by TRUSTout of 910 syphilis serum specimens with a positive rates of 84.9 % and a specificity of 96.1%;while there 889 specimens were positive detected by TPPA with the sensitivity and specificity of 98.7 %,there were significant differences in the outcomes between TPPA reagent and TRUST reagent.The specificities and the sensitivities of TPPA were 99.6% and 98.7%;higher than that of TRUST(84.9% and 96.1%).Conclusion TPPA in combination with TRUST is valuable for detecting and diagnosing of human syphilis.