Effect of Hyperuricemia on serum nitric oxide levels in diabetic patients with hyperlipidemia

Abstract Introduction Recent studies have shown that elevated serum uric acid is associated with insulin resistance, hyperlipidemia, obesity, hypertension & cardiac diseases. The elevated level of uric acid is a risk factor in diabetes mellitus. Hyperuricemia if not corrected can inactivate nitric oxide (NO) which leads to hyperlipidemia & increases the risk of cardiac diseases by affecting endothelial function & arterial stiffness. Objectives The aim of our study was to determine whether hyperuricemia depletes serum NO level in diabetic patients and to find out correlation between the levels of NO in study group. Methods Total ninety patients were selected and divided in to three groups. Group I (n=30) - Controls; Group II (n=30) - Diabetic patients with hyperlipidemia & hyperuricemia; Group III (n=30) - Diabetic patients with hyperlipidemia & normouricemia. The values of fasting sugar, lipid profile, serum uric acid were estimated by auto analyzer using transasia kits. Serum NO is estimated by Cortas & Wakid method. Result It is observed that Group II showed highly significant decreased levels of serum NO (p 0.05). Comparison between Group II & Group III showed significantly declined NO level in Group II (p< 0.0001). Conclusion Our results suggests that diabetic patients with hyperlipidemia & hyperuricemia shows low levels of serum NO & indicates that hyperuricemia inactivates serum NO and decreases it’s bioavailability.