Experimental Combinatorial Methods in Molecular Imprinting

Combinatorial techniques to synthesize and evaluate molecularly imprinted polymer sorbents for various molecular recognition based applications are reviewed. Various techniques to screen for binding and imprinting effects are discussed with reference to the application for which the sorbents are intended. State of the art high throughput synthesis techniques are outlined, and examples of how these have been used to identify suitable polymer building blocks or to optimize prepolymerization compositions to improve the molecular recognition properties in a given matrix are given.