T Lymphocytes: Regulatory

CD4+ regulatory (Treg) T cells play a central role in the immune system by potently controlling the responses of other immunocytes. Their activity appears to be essential not only for the maintenance of immunological self-tolerance but potentially also for the control of all physiological immune responses whether against normal self-proteins, microbes or cancerous cells. A fuller understanding of these cells should allow us to effectively exploit their suppressive functions for clinical benefit. Keywords: CD25+CD4+T cell; Foxp3; IPEX; regulatory T cell; self-tolerance