Probing the roles of SUMOylation in cancer cell biology by using a selective SAE inhibitor

Xingyue He,Jessica Riceberg,Teresa A. Soucy,Erik Koenig,James Minissale,Melissa Gallery,Hugues Bernard,Xiaofeng Yang,Hua Liao,Claudia Rabino,Pooja Shah,Kristina Xega,Zhong-Hua Yan,Mike Sintchak,John Bradley,He Xu,Matt Duffey,Dylan England,Hirotake Mizutani,Zhigen Hu,Jianping Guo,Ryan Chau,Lawrence R. Dick,James E. Brownell,John Newcomb,Steve Langston,Eric S. Lightcap,Neil F. Bence,Sai Pulukuri

Probing the roles of SUMOylation in cancer cell biology by using a selective SAE inhibitor

2017

An inhibitor of the SUMO-activating (E1) enzyme SAE blocks enzyme activity and total SUMOylation in cells—thereby defining roles for SAE in mitotic progression and chromosome segregation—and also decreases cancer cell proliferation.

Keywords:

Molecular biology
Cancer cell
Enzyme
Mitosis
Biology
SUMO protein
Cell biology
Chromosome
Enzyme assay
Cell growth
DNA damage
Chromosome segregation

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