The synthesis of (R)-(−) and (S)-(+)-hydroxysaclofen
1995
Abstract 2-(4-Chlorophenyl)-3-hydroxypropene has been separately converted to both enantiomers of its epoxide. The epoxides were converted to (R)-(−) and (S)-(+)-hydroxysaclofen. Only the latter showed activity as a specific GABA B antagonist.
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