Antiamebic Agents IV* Quinolines and acridines with amino-hydroxyalkylanilino side chains†

Six quinolines and five acridines containing side chains incorporating some of the structural features of amodiaquin and SN-8,137 were synthesized as potential antiamebic or antimalarial agents. The antiamebic activity of the compounds tested was insufficient to offer promise. Two possessed antimalarial activity in chicks greater than quinine, but insufficient for further interest.