12-Lipoxygenase Inhibitor Improves Functions of Cytokine-Treated Human Islets and Type 2 Diabetic Islets

Kaiwen Ma,An Xiao,So Hyun Park,Lindsey Glenn,Laura Jackson,Tatvam Barot,Jessica R. Weaver,David A. Taylor-Fishwick,Diane K. Luci,David J. Maloney,Raghavendra G. Mirmira,Yumi Imai,Jerry L. Nadler

12-Lipoxygenase Inhibitor Improves Functions of Cytokine-Treated Human Islets and Type 2 Diabetic Islets

2017

Kaiwen Ma
An Xiao
So Hyun Park
Lindsey Glenn
Laura Jackson
Tatvam Barot
Jessica R. Weaver
David A. Taylor-Fishwick
Diane K. Luci
David J. Maloney
Raghavendra G. Mirmira
Yumi Imai
Jerry L. Nadler

Context: The 12-lipoxygenase (12-LO) pathway produces proinflammatory metabolites, and its activation is implicated in islet inflammation associated with type 1 and type 2 diabetes (T2D).

Keywords:

Endocrinology
Internal medicine
Cytokine
Diabetes mellitus
Lipoxygenase
Medicine
Islet
In vivo
Inflammation
Proinflammatory cytokine
Type 2 diabetes
In vitro

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