3-Imidazolylmethylaminophenylsulfonyltetrahydroquinolines, a Novel Series of Farnesyltransferase Inhibitors

Design, synthesis and structure-activity relationship of a series of 3-imidazolylmethylaminophenylsulfonyltetrahydroquinolines as farnesyltransferase inhibitors are presented. A working pharmacophore of inhibiting farnesyltransferase by this series of inhibitors is proposed.