The sequence of the Aγ globin gene in a Gγβ+ type of hereditary persistence of fetal haemoglobin

Summary The sequence of the Aγ globin gene from the affected chromosome of an individual heterozygous for the Gγβ+ type of hereditary persistence of fetal haemoglobin (Gγβ+ HPFH) is reported. With two exceptions, it is identical to one of the two allelic Aγ globin genes already sequenced and there is therefore no change which could explain the absence of its expression in the face of the persistent Gγ globin expression which is a feature of this condition.