SYNTHESIS AND ANTIARRHYTHMIC ACTIVITY OF CIS-2,6-DIMETHYL-ALPHA ,ALPHA -DIARYL-1-PIPERIDINEBUTANOLS

Structure-activity relationship studies indicated that the 2,6-dimethylpiperidine group yielded compounds with the best antiarrythmic profiles in this series. The length of the methylene chain separating the diarylcarbinol and the amino group was not crucial. Substitution of a hydrogen or a number of functional groups for the hydroxyl group had little effect on efficacy or duration but yielded compounds that produced severe tachycardias. Replacement of one of the aryl groups by hydrogen or a pyridinyl or cyclohexyl group had little effect on efficacy but decreased the duration of action