SEPT12/SPAG4/LAMINB1 Complexes are Required for Maintaining the Integrity of the Nuclear Envelope in Postmeiotic Male Germ Cells

Male infertility affects approximately 50% of all infertile couples. The male-related causes of intracytoplasmic sperm injection failure include the absence of sperm, immotile or immature sperm, and sperm with structural defects such as those caused by premature chromosomal condensation and DNA damage. Our previous studies based on a knockout mice model indicated that SEPT12 proteins are critical for the terminal morphological formation of sperm.