Block catiomer with flexible cationic segment enhances complexation with siRNA and the delivery performance in vitro

Wenqian Yang,Takuya Miyazaki,Chen Pengwen,Taehun Hong,Mitsuru Naito,Yuji Miyahara,Akira Matsumoto,Kazunori Kataoka,Kanjiro Miyata,Horacio Cabral

Block catiomer with flexible cationic segment enhances complexation with siRNA and the delivery performance in vitro

2021

Wenqian Yang
Takuya Miyazaki
Chen Pengwen
Taehun Hong
Mitsuru Naito
Yuji Miyahara
Akira Matsumoto
Kazunori Kataoka
Kanjiro Miyata
Horacio Cabral

RNA interference (RNAi) by small interfering RNAs (siRNAs) is a promising therapeutic approach. Because siRNA has limited intracellular access and is rapidly cleared in vivo, the success of RNAi de...

Keywords:

In vivo
Chemistry
In vitro
Intracellular
Cationic polymerization
Cell biology
Clearance
Small interfering RNA
RNA interference

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