Диагностика фиброза печени у детей с болезнью Вильсона

The data of the examination of 89 children aged 5-18 years (mean age: 12,3 ± 2,9 years), with the Wilson''s disease to determine the diagnostic possibilities of ultrasound quantitative evaluation of stages of liver fibrosis with the use of the Acoustic Structure Quantification (ASQ) are presented. Liver ultrasound examination was performed with the help of the diagnostic expert system Toshiba Aplio XG V4 with the ASQ function, which included the histogram construction, color coding and determination of density index (DI) of the liver parenchyma. The analysis of ASQ was established to be of the diagnostic value in the examination of children with the Wilson''s disease. Color coding allows you to visually assess the degree of advancing of fibrosis and the number of functioning liver tissue. The more liver tissue is homogeneic, the variation in the histogram and Rayleigh curve is smaller, and vice versa: the more there are variations, fibrosis is the more advanced. The revealed link between DI and histological pronouncement of fibrosis allows to recommend it as a noninvasive marker of fibrosis advancement in monitoring the acoustic structure of the liver in the dynamics of the course of the Wilson 's disease in the each personal patient.