Comments on "Association of FcepsilonRIbeta polymorphisms with risk of asthma and allergic rhinitis: evidence based on 29 case-control studies".

Guo H. et al. (Bioscience reports (2018) 38, BSR20180177) published a meta-analysis concerning the association between 5 nucleotide polymorphisms (SNPs) in the high-affinity IgE receptor beta chain (FceRIβ) gene, namely E237G, -109 C/T, RsaI_in2, RsaI_ex7, and I181L, and risk of asthma and allergic rhinitis based on available 29 case-control studies. Summary odds ratios (ORs) and 95% confidence intervals (CIs) were used to assess the strength of association of SNPs in FceRIβ gene with allergic diseases risk. They found that FceRIβ E237G (237G versus 237E: OR=1.28, 95% CI=1.06-1.53) and -109 C/T (TT vs. CT+CC: OR=1.58, 95% CI=1.26-1.98) were risk factors for allergic diseases. Guo H. et al.'s findings are interesting, but we found that several issues should be clarified after careful reading the paper. Here we intended to comment on these data clarifications.