The Role of the IL-12 polymorphism rs3212227 in preeclampsia in Chinese Han Women

ABSTRACTObjective: To investigate whether IL-12B rs3212227 was associated with susceptibility to PE (preeclampsia) in Chinese Han women. Methods: We enrolled 1000 PE patients and 1287 controls and performed rs3212227 genotyping by PCR–restriction fragment length polymorphism. Results: No significant differences in genetic distributions of IL-12B rs3212227 were observed between cases and controls (χ2 = 4.62, p = 0.10 by genotype; χ2 = 0.03, p = 0.87 by allele). There were also no significant differences in genotypic and allelic frequencies between mild/severe or early/late-onset PE and control subgroups. Conclusion: Our data suggested that IL-12B rs3212227 might not be a critical risk factor for PE in Chinese Han women.