A novel approach to observing articular cartilage deformation in vitro via magnetic resonance imaging.
1999
: The design of a pressure cell that compresses a cartilage specimen in one dimension within an imaging magnet is presented. One-dimensional projection images in a direction perpendicular to the articular surface of the cartilage specimen were used to generate a uniaxial confined deformation creep curve for normal and trypsin-degraded cartilage specimens during a continuous 0.690 MPa (100 psi) pressure application. The resulting curves are shown to fit a two time constant viscoelastic model well and also indicate that the elastic modulus of cartilage decreases and the deformation rate increases upon trypsin proteolysis. Furthermore, cartilage permeability is shown as a function of cartilage strain for both the normal and trypsin-degraded case. Several two-dimensional slice-selective images were collected both before and after 80 minutes of continuous compression. These images were used to evaluate the relative changes in the spin-lattice, T1, and spin-spin, T2, relaxation time constant maps for both normal and degraded cartilage specimens in response to compression. The results of this study demonstrate the utility of a novel, non-magnetic, cartilage compression device and also support the validity of a simple two-component rheological model of articular cartilage.
Keywords:
- Radiology
- Osteoarthritis
- Cartilage
- Permeability (electromagnetism)
- Delayed Gadolinium Enhanced Magnetic Resonance Imaging of Cartilage
- Medicine
- Nuclear magnetic resonance
- Deformation (mechanics)
- Magnetic resonance imaging
- Anatomy
- Biomedical engineering
- Elastic modulus
- Viscoelasticity
- Compression (physics)
- Pathology
- Correction
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