Dosimetric comparison of different treatment modalities for stereotactic radiosurgery of arteriovenous malformations and acoustic neuromas

Abstract Purpose We investigated the influence of beam modulation on treatment planning by comparing four available stereotactic radiosurgery (SRS) modalities: Gamma-Knife-Perfexion, Novalis-Tx Dynamic-Conformal-Arc (DCA) and Dynamic-Multileaf-Collimation-Intensity-Modulated-radiotherapy (DMLC-IMRT), and Cyberknife. Material and methods Patients with arteriovenous malformation ( n =10) or acoustic neuromas ( n =5) were planned with different treatment modalities. Paddick conformity index (CI), dose heterogeneity (D H ), gradient index (GI) and beam-on time were used as dosimetric indices. Results Gamma-Knife-Perfexion can achieve high degree of conformity (CI=0.77±0.04) with limited low-doses (GI=2.59±0.10) surrounding the inhomogeneous dose distribution (D H =0.84±0.05) at the cost of treatment time (68.1min±27.5). Novalis-Tx-DCA improved this inhomogeneity (D H =0.30±0.03) and treatment time (16.8min±2.2) at the cost of conformity (CI=0.66±0.04) and Novalis-TX-DMLC-IMRT improved the DCA CI (CI=0.68±0.04) and inhomogeneity (D H =0.18±0.05) at the cost of low-doses (GI=3.94±0.92) and treatment time (21.7min±3.4) ( p H =0.22±0.02) dose distribution and treatment time (28.4min±8.1) ( p Conclusions Gamma-Knife-Perfexion will comply with all SRS constraints (high conformity while minimizing low-dose spread). Multiple focal entries (Gamma-Knife-Perfexion and Cyberknife) will achieve better conformity than High-Definition-MLC of Novalis-Tx at the cost of treatment time. Non-isocentric beams (Cyberknife) or IMRT-beams (Novalis-Tx-DMLC-IMRT) will spread more low-dose than multiple isocenters (Gamma-Knife-Perfexion) or dynamic arcs (Novalis-Tx-DCA). Inverse planning and modulated fluences (Novalis-Tx-DMLC-IMRT and CyberKnife) will deliver the most homogeneous treatment. Furthermore, Linac-based systems (Novalis and Cyberknife) can perform image verification at the time of treatment delivery.