Comparison between GFR Values Obtained by CG-formula and DTPA Renography in Different Renal Disorders

Aim: The present study aims at comparing the glomerular filtration rate (GFR) values obtained by using Cockcroft-Gault (CG) formula and DTPA renography in different renal disorders. Material and method: This retrospective study consists of 50 patients diagnosed with renal disorders. Out of 50 patients, 25 were males (50%) in the age range of 7 to 60 with the mean age of 31±16 and remaining 25 were females (50%) in the same age range with the mean age of 34±14 refered to us for various renal disorders. Renal scans were done using Siemens dual head gamma camera (E.CAM). The radio pharmaceutical 99m Tc-DTPA was used and injected intravenously. The dose used for the adults was in the range of 3 to 5 mCi (111 to 185 MBq) and the dose used for the children was in the range of 1 to 3 mCi (37 to 111 MBq), the images were processed by using GFR/Renal differetial processing protocol in icon software. Result: The mean total GFR by DTPA Gates method was 71.3 ± 20.8 ml/min and by the Cockroft Gault (CG) method was 73 ± 20.2 ml/min. The difference was statistically insignificant indicating an agreement between both the methods in measuring GFR. Conclusion: The results of the present study suggests that the Gates method used in DTPA renography provides almost equal estimation of GFR in patients with different renal disorders when compared to CG method.