The preparation method of 6 nitro, 1,2,3,3 tetramethyl indoles

The present invention relates to a kind of preparation method of 1,2,3,3 tetramethyl indoles of 6 nitro, with 1,2,3,3 tetramethyl indoles are raw material, using sulfuric acid as solvent, using the nitration mixture of certain concentration as nitrating agent, nitration mixture is added dropwise within a certain period of time and carries out nitration reaction 6 nitros 1,2,3 of generation, 3 tetramethyl indoles, reaction solution is diluted in a certain amount of frozen water and is filtered to remove byproduct, and the reaction solution after filtering obtains 6 nitros 1 by anti-tune, 2,3,3 tetramethyl indoles.Present invention process is simple, product post processing is easy, environmental pollution is small, 6 nitros 1,2 being prepared, 3,3 tetramethyl indoles product quality qualities are high, and stability is good, and obtained product is in addition to it can be used for general applications, the preparation of high-end resin is can be also used for, is a kind of method of suitable preparation of industrialization.