TMIC-10. AUTOPSY STUDY ON THE EFFECTS OF TUMOR TREATMENT FIELDS IN RECURRENT GLIOBLASTOMA: PRELIMINARY RESULTS

BACKGROUND Treatment of recurrent glioblastoma using tumor treatment fields (TTFields) has recently been approved. This resulted from a recent clinical trial that showed better quality of life and comparable overall survival. Low-intensity, alternating frequency electric fields, known as TTFields, have been shown to disrupt cell division and subsequently tumor growth. Apoptosis and cell cycle arrest have been seen in vitro, and shown in mice and rabbit tumor models. Glioblastoma patients who have undergone TTField therapy have not yet been assessed at autopsy to determine both the pathological signature of TTField therapy, and the pattern of failure.