654 Hormonal-metabolic status in smoking and non-smoking breast cancer (BC) patients with normal (N) and excessive (E) body mass: Possible prognostic significance

Survival is decreased in smokers and obese patients with BC. We compared indices of hormonal-metabolic status in 118 pts with BC, 35 of whom smoked and 43 have had Quetelet index » 32. PreMP BC pts with E demonstrated greater than postMP pts increase in body fat content, LBM, waist/hip ratio, blood glucose and free cortisol exeretion in relation to these values in pts with N. In postMP obese pts increase in reactive insulinemia and triglyceridemia was expressed more than in corresponding group of preMP pts. Smoking increased waist/hip ratio and decreased ER coment in tumor tissue in greater degree in pre- and postMP pts with N than with E. The lowest level of FSH and LH and highest of estradiol in blood was discovered in smokers with E. Thus, different hormonal-metabolic mechanisms can mediate devastating effect of body mass excess and smoking on prognosis in pre- and postMP type of BC.