Three-component assembly of structurally diverse 2-aminopyrimidine-5-carbonitriles.

Cristina Val,Abel Crespo,Vicente Yaziji,Alberto Coelho,Jhonny Azuaje,Abdelaziz El Maatougui,Carlos Carbajales,Eddy Sotelo

Three-component assembly of structurally diverse 2-aminopyrimidine-5-carbonitriles.

2013

Cristina Val
Abel Crespo
Vicente Yaziji
Alberto Coelho
Jhonny Azuaje
Abdelaziz El Maatougui
Carlos Carbajales
Eddy Sotelo

An expedient route for the synthesis of libraries of diversely decorated 2-aminopyrimidine-5-carbonitriles is reported. This approach is based on a three-component reaction followed by spontaneous aromatization.

Keywords:

Aromatization
Combinatorial chemistry
Biginelli reaction
Chemistry
Organic chemistry
Combinatorial Chemistry Techniques
Small Molecule Libraries

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