Study of ADMET Descriptors of Novel Chlorinated N -Arylcinnamamides

(2E)-3-(3,4-Dichlorophenyl)-N-arylprop-2-enanilides were designed as potential bioactive agents. Six compounds were mono- and di-chlorinated also on the anilide ring. Since the biological activities of molecules are influenced by lipophilicity, the hydro-lipophilic characteristics of these compounds were experimentally studied. In addition, the overall ADMET (absorption, distribution, metabolism, excretion, toxicity) profiles of these molecules were studied to establish whether they comply with the Lipinski’s rule of five and thus meet the “druglikeness” requirement. All the compounds were analyzed using the reversed-phase high performance liquid chromatography method. The procedure was carried out under isocratic conditions and a C18 stationary reversed-phase column. The structure–lipophilicity relationships of the investigated compounds are discussed.