Effect of Dengzhan Xixin Injection on ALT and AST Evaluated by Propensity Scoring:An Analysis of 1641 Cases

Objective To explore the effect of Dengzhan Xixin Injection(DXI) on liver function of patients during clinical application. Methods From the hospital information system(HIS) of 20 nationwide grade-three class-A hospitals,a total of 21498 cases medicated by DXI were chosen as the observation group. And then we analyzed the serum levels of alanine aminotransferase(ALT)and aspartate aminotransferase(AST)of 1641 cases from 21498 patients that aged 18 to 80 years and having liver function testing at least twice during time interval ≥7 days before and after DXI treatment. Classic logistic regression analysis, and weighted logistic regression analysis based on generalized boosted models(GBM)of propensity scoring with or without concomitant variable were used for evaluating the influence of DXI on ALT and AST. Results The results of the three methods showed that P value was over 0.05 and the difference was statistically significant. Conclusion The existing electronic medical data of HIS indicated that DXI may have an effect on ALT and AST.