Inhibition of CWR22Rν1 tumor growth and PSA secretion in athymic nude mice by green and black teas

Dietary modulation of cancer & cancer biomarkers Dietary item or component studied: green tea polyphenols (GTP), water extract of black tea, and their major constituents epigallocatechin-3-gallate and theaflavins, respectivelyOutcome studied (cancer or cancer biomarker): Cancer of the prostate gland (CaP)Study type (in vitro, animals, humans): male athymic nude miceMode of exposure (if in vivo): administration through waterImpact on outcome (including dose-response): GTP, BTE and TF mice compared with untreated mice were statistically significant with P < 0.01 according to a log-rank analysisGTP treatment was most effective among the agents tested (P < 0.001).PSA in control animals was found to be 13.95 ± 0.82 ng/ml; animals treated with GTP, BTE, EGCG and TF, the PSA levels were found to decrease significantly to 4.95 ± 1.23, 6.37 ± 1.75, 4.07 ± 0.98 and 5.9 ± 0.78 ng/ml, respectively (P < 0.01).At day 24, the level of PSA in control was 26.4 ± 1.32 ng/ml; in animals treated with GTP, BTE, EGCG and TF, the PSA levels were significantly decrease respectively to 4.46 ± 1.32, 8.85 ± 2.32, 5.7 ± 0.58 and 6.9 ± 1.32 ng/ml (P < 0.01). KEYWORDS CLASSIFICATION: analogs & derivatives;Animals;Anticarcinogenic Agents;Apoptosis;bcl-2-Associated X Protein;biosynthesis;Biflavonoids;chemistry;Catechin;drug effects;Dermatology;dietary modulation of cancer & cancer biomarkers;dietary modulation of carcinogenesis-related pathways;Flavonoids;Male;Mice;Mice,Nude;pharmacology;prevention & control;Phenols;Prostate-Specific Antigen;Prostatic Neoplasms;Proteins;Proto-Oncogene Proteins;Proto-Oncogene Proteins c-bcl-2;Research;secretion;Tea;Up-Regulation;