Long-term evolution of transmitted CXCR4-using HIV-1 under effective antiretroviral therapy

Objective:To study the long-term evolution of the transmitted CXCR4-using viruses. CCR5-using viruses (R5 viruses) predominate during primary HIV-1 infections (PHI) while CXCR4-using viruses are isolated in less than 10% of PHI.Design:Six patients infected with an R5X4 virus, detected by a sensitive