M1803 Differential Degradation of Anti-Tumor Necrosis Factor-α Agents by Matrix Metalloproteinase-12 in Inflammatory Bowel Disease

DIFFERENTIAL DEGRADATION OF ANTI-TUMOR NECROSIS FACTOR-ALPHA AGENTS BYMATRIXMETALLOPROTEINASE-12 IN INFLAMMATORY BOWEL DISEASE P. Biancheri∗ ,1, A. Di Sabatino2 , L. Rovedatti 2 , N. Ahmad1, G. Corazza2 , T. MacDonald1 1Centre for Immunology and Infectious Disease, BICMS, Barts and the London School of Medicine and Dentistry, London, UK; 2First Department of Medicine, S. Matteo Hospital, University of Pavia, Pavia