Synthesis and Antioxidant Activity of 3,3’-Diselanediylbis (N,N-Disubstituted Indolizine-1-carboxamide) and Derivatives

A series of novel diselenides 5a–e were synthesized from -haloketones, -picoline alkenes and various secondary amines under a dry nitrogen atmosphere. The structures of these compounds were established by means of their spectral data and they were screened for scavenging activity against 1,1-diphenyl-2-picryl-hydrazyl (DPPH . ). The results of this research showed that two of these compounds (5e and 5d) exhibited reasonable antioxidant activity. The intermediate, methyl 5-methylindolizine-1carboxylate was prepared by condensation of methyl acrylate with 1-(carboxymethyl)-2-methylpyridinium halide, which was prepared from -picoline and chloroacetic acid by using the Tschischibabin reaction.