Drug delivery nanosystems for musculoskeletal regeneration

Abstract Over the last decades, regenerative medicine has become an important part of viable interventions in musculoskeletal disorders. Musculoskeletal regeneration research is a rapidly growing field within medicine, aimed at repairing, regenerating, or replacing skeletal elements and associated tissues that are affected by musculoskeletal injury or degradation. Studying on design and fabrication of the drug delivery vehicles, drug loading strategies, drug release profiles, and retaining the bioactivity of the drugs are parts of the research efforts in regenerative medicine. In musculoskeletal conditions the capacity of tissue for regeneration varies among tissues. Whereas small injuries in long bones and skeletal muscle can heal easily, the tissue regeneration in large defects, cartilage, and tendon remains a big challenge. This chapter discusses using various types of nanosystems including polymer, ceramic, metal, and hybrid materials in different morphology for musculoskeletal regeneration drug delivery.