Significance of BNP for Neurological Severity in Acute Ischemic Stroke (I2.009)

BACKGROUND and OBJECTIVE: Although previous studies have shown brain natriuretic peptide (BNP) level was useful for a diagnosis of the subtype in ischemic stroke, only a few studies have reported the relationship between BNP level and a severity of acute stroke. We therefore investigated the association of BNP level and the severity of stroke patient in acute stage. METHODS: Of 553 stroke patients admitted to the Kyushu Medical Center from January 2013 to August 2014, 390 patients (246 males; 71 ± 12 years old) who were independent at daily life (modified Rankin Scale 3 on admission. RESULTS: Each group had the following BNP levels on admission: Q1 < 19.2 pg/ml, 19.2 pg/ml ≤ Q2 < 43.1 pg/ml, 43.1 pg/ml ≤ Q3 < 110.3 pg/ml, 110.3 pg/ml ≤ Q4. On logistic regression analysis after adjustments for multiple confounding factors (age, sex and other risk factors), Q2 (odds ratio [OR] 2.05, 95[percnt] confidence interval [CI] 1.11 to 3.89, p < 0.05), Q3 ([OR] 2.11, 95[percnt] [CI] 1.06 to 4.28, p < 0.05) and Q4 ([OR] 6.63, 95[percnt] [CI] 2.95 to 15.4, p < 0.01) groups were at greater risk of stroke severity compared with the Q1 group. CONCLUSIONS: There is a significant relationship between BNP level and the neurological severity of stroke in acute stage. A high BNP level in the acute phase increases the risk of worse stroke severity. Disclosure: Dr. Kuwashiro has nothing to disclose. Dr. Yasaka has nothing to disclose. Dr. Ito has nothing to disclose. Dr. Tokunaga has nothing to disclose. Dr. Takaguchi has nothing to disclose. Dr. Nakamura has nothing to disclose. Dr. Gotoh has nothing to disclose. Dr. Okada has nothing to disclose.