SHOULD HIGHER VANCOMYCIN TROUGH LEVELS BE TARGETED FOR INVASIVE COMMUNITY-ACQUIRED METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS INFECTIONS IN CHILDREN?

Methicillin-resistant Staphylococcus aureus (MRSA) isolates with vancomycin minimal inhibitory concentrations (MIC's) ≥ 1.5 μg/mL have been associated with poorer clinical outcomes and treatment failures in adults. We evaluated vancomycin MIC's in 71 invasive pediatric community-acquired MRSA (CA-MRSA) isolates from 2004-2008 using the E-test micro-method and the E-test macro-method. The modal MIC by micro-method was 1.5 μg/mL, and median vancomycin MIC's did not increase over time.