The Observation of Adrenomedullin (15-32) Level in Nautical Personnel with Essential Hypertension

Objective: To observe the pathophysiological significance and levels of plasma adrenomedullin [ADM (13-52)] in 39 nautical personnel with essential hypertension. Methods: The concentration of plasma ADM (13-52) was measured with special radioimmunoassay. Results: The plasma ADM (13-52) levels (30.67±1.37) ng/L in 39 nautical personnel with essential hypertension were significantly higher than those in normal nautical personnel (18.98± 1.10) ng/L (P0.01), and was well increased with the clinical stages or severity of the disease (P0.01). There was a positive correlation between plasma ADM (13-52) level, pulse pressure, and endothelin (ET) level (r = 0.553,0.567,P0.01). Conclusion: ADM (13-52) is a kind of dilative peptide, the elevation of plasma ADM (13-52) in patients with essential hypertension may be part of compensatory mechanism to maintain the body stability.