The Association of Genetic Polymorphisms in the κ-Opioid Receptor 1 Gene With Body Weight, Alcohol Use, and Withdrawal Symptoms in Patients With Methadone Maintenance

AbstractMethadone is a synthetic opioid that binds to the κ-opioid receptor with a low affinity. This study tested the hypotheses that the genetic polymorphisms in the κ-opioid receptor 1 (OPRK1) gene region are associated with methadone treatment responses in a Taiwan methadone maintenance treatmen