Biliary excretion of infused conjugated sulfobromophthalein in sheep heterozygote for the transport defect present in mutant Corriedale sheep.

Biliary excretion of dye was measured in 2 clinically normal and 2 heterozygote Corriedale sheep (the mutant Corriedale is characterized by depressed biliary transport of conjugated sulfobromophthalein (SBP) compounds) during infusion of the preformed glutathione conjugate of SBP. Maximal rates of excretion of conjugated SBP compounds in bile were comparable in heterozygote Corriedale and clinically normal sheep. These 2 heterozygote sheep do not express the biliary transport defect observed in mutant Corriedale sheep during SBP-glutathione infusion.