Immunotoxicology of JP-8 Jet Fuel: Mechanisms

Abstract : Experiments were performed exposing mice to varying doses of either JP-8 or S-8 jet fuel for 1h/day for 7 days, using the new exposure apparatus with in-line monitoring of jet fuel concentrations (aerosol and vapor). Six controls, 6 JP-8 exposed and 6 S-8 exposed animals examined. There were no significant effect on body weight due to JP-8 or S-8 exposure, and no effect on immune cell viability from any immune organ due to JP-8 or S-8 exposure. There was a 53% decrease in Spleen weight due to S-8 exposure and a corresponding 40% decrease due to JP-8 exposure. There was a 36% decrease in Thymus weight due to S-8 exposure and a corresponding 60% decrease due to JP-8 exposure. There was a 64% decrease in Thymus cell numbers due to S-8 exposure and a corresponding 46% decrease due to JP-8 exposure. There was a 20% decrease in Spleen cell numbers due to JP-8 exposure only. No significant change in composition in any immune organ due to JP-8 or S-8 exposure. Both JP-8 and S-8 exposures using the new exposure chamber resulted in changes in immune function.